The origin of the Our Lady (Mother) of Perpetual Help icon is uncertain, although many have thought that it was painted by St. Luke and venerated in Constantinople until that Holy City fell in 1453. The Byzantine style and Greek lettering are consistent with an icon of Eastern origin.
While we may not know the exact origins of Our Mother of Perpetual Help, we do know the next part of the story -- from the original picture itself. A parchment attached to the painting tells the story of how it got to Rome.  
For the complete story see http://www.kourlp.org/pages/whyourlady.html

Beautifully hand blown and decorated with Swarovski crystals.  Created in the Edward Bar Design Studio in Krakow.